Raymond A. Spiteri writews >We are seeking a less hazardous alternative to xylene to be used in >solvent mixtures and for dissolving acrylic resins like Paraloid B72 >for eventual use in conservation treatments. Even though the negative health effects of xylene have been known for more than 60 years, some labs continue to use this solvent when alternatives exist. Are you using it only on the stainers or for tissue processing as well. The active ingredient in Delsym is dextromethorphan hydrobromide, an anti-cough agent approved by the FDA in 1982 3 4. Polychem’s xylene replacement product lasts 7-10 times longer than comparable solvent products. With the formula (CH 3) 2 C 6 H 4, each of the three compounds has a central benzene ring with two methyl groups attached at substituents.They are all colorless, flammable liquids, some of which are of great industrial value. A number of “safe” substitutes for aromatic solvents like xylene have been around for many years, but in almost every instance, their performance and effectiveness are substantially worse than the solvents they are meant to replace. Search results for xylene at Sigma-Aldrich. Substitute immutable groups in chemical compounds to avoid ambiguity. Environmental XPRT is a global environmental industry marketplace and information resource. Xylene (from Greek ξύλο, xylo, "wood"), xylol or dimethylbenzene is any one of three isomers of dimethylbenzene, or a combination thereof. It causes injury to various agricultural and ornamental crops. The tracking dye typically migrates with the DNA molecules around 5kb. Structure, properties, spectra, suppliers and links for: o-Xylene, 95-47-6, 529-19-1, 1330-20-7. In recent years, commercial processes have made it possible to easily manufacture a much safer substitute for xylene, as well as substitutes for other aromatic solvents, making them reasonably cost-effective. Enter your email to restore your password. From Solvents. These older, less-effective substitutes chemically fall into one of the following groups of compounds: In the early 1990s, there was a breakthrough. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. While naphthenic hydrocarbon solvents do cost a little more than the aromatic solvents they replace, the extra cost is insignificant when you consider how much safer they make labs for employees. Xylene Cyanol FF is used as a tracking dye to monitor the progress of electrophoresis separations. (Formula 78H, which has the higher boiling point is marketed actually as a substitute for higher boiling aromatic solvents of the high-flash naphtha type, eg. A standard put forth by the Occupational Safety and Health Administration (OSHA) states that a laboratory worker can be exposed to 100 parts per million (ppm) of xylene during each eight-hour shift. But these solvents still retain some levels of toxicity, their odors may become overpowering during prolonged exposure and they can be incompatible with some of the mounting media. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Twenty of the 30 substitutes for xylene on the market today are safer than using xylene itself. Xylene, also referred to as xylol, is any of three different isomeric liquid substances used as a solvent in the manufacture of dyes, resins, insecticides, fuels, perfumes and films. What are the most important things to know about xylene in an emergency? The official Delsym site notes that its product is formulated as either orange or grape flavored time-released syrup available in 3-ounce … (3.79 L) Ea. When combined with solvent recycling, they can help ensure your lab is both safe and running cost-effectively. I don't know anything about the product 'Clarify', but in the United States I am aware of a couple of 'xylene substitute' solvents offered by CBG Technologies in Ohio: Formula 83 and Formula 78H. The ProCycler series relies on its high efficiency distillation columns to remove unwanted contaminants from xylene substitutes. It also has high chronic (long-term) toxicity to aquatic life. (3.79 L) 4/cs. Xylene is expected to moderately bioaccumulate, in fish. Can anyone suggest, or >has used, a viable alternative. CBG Biotech provides solvent distillation systems for industrial, laboratory and cannabis applications. Model Formula 83 - Clearing Solvent. Chemically, these newer, safer solvents are naphthenic hydrocarbons. Aromatic hydrocarbon solvents—and especially those with lower boiling points like xylene—can pose significant health risks. Today, histology, pathology, cytology, research, veterinary, parasitology and dermatopathology labs should work to provide a safe environment for personnel by helping them avoid the toxic and dangerous effects of xylene. Safe and HAP-Free Solvents that Replace (Substitut... No orange smell, nor oily residue, nor sticking, About 3-times more effective than paraffinic, About 2-times more effective than limonene. This research led to the development of naphthenic solvents that are similar in performance. More frequent changes may be necessary. Xylene definition, any of three oily, colorless, water-insoluble, flammable, toxic, isomeric liquids, C8H10, of the benzene series, obtained mostly from coal tar: used chiefly in the manufacture of dyes. This study investigated the use of 7 xylene substitutes of 2 classes, limonenes and alkanes, for paraffin tissue processing. • Thermo Scientific Shandon Xylene Substitute Mountant Warnings and Precautions See Safety Data Sheets for warnings and precautions, as well as EUH code definitions. Order Information Product Size Qty. Shop a large selection of products and learn more about Cbg Biotech FORMULA 83 XYLENE SUB 4X1GAL FORMULA 83 XYLENE SUB 4X1GAL . But only one option is as good as or better than xylene itself. *Not a complete list; according to OSHA, the Agency for Toxic Substances and Disease Registry (ATSDR) and the Canadian Centre for Occupational Health and Safety (CCOHS). Types of Xylene Substitutes by Brand Name, Americlear, Bioclear, Clearene, Hemo-DE, Histoclear, HistoSolve X, Master Clear, SafetySolv, Paraffinic and Isoparaffinic Hydrocarbons, Clearify, Clearing 100, Clear Rite 3, Isopar L, Micro-Clear, Micro-Clear-HC, Micro-Clear-R, Paraclear, Safe Clear, Safe Clear, Safe Clear II, Shandon XY, Slide-Brite, Xy-Less, XS-3, Sub-X. 6764506 Xylene Substitute 5 gal. No reviews were found for Model Formula 83 - Clearing Solvent. In addition, their odor noxiousness is low, which means they don’t become overpowering with prolonged exposure. We used the Formula 83 for about a year and we were happy with it. May 25, 2018 / by Manufactured by CBG Biotech Was designed to be a safe substitute to Xylene, claims that Formula 83 is as equally good or better in almost every use as a laboratory solvent. Compare Products: Select up to 4 products. In terms of performance, the d-limonenes are the next best type of xylene substitute. XPRT, Biological Oxygen Demand (BOD) Monitoring. D-limonene solvents also dry very slowly compared to xylene and they often leave an oily residue. Subject: [Histonet] Formula 83: xylene substitute Hello Everyone, I would like to get some feedback from Formula 83 users. Although several xylene substitutes are now available, a comprehensive evaluation of them has yet to be published. on it. Figures in the table less than 1.0 indicate performance superior to xylene and figures in the table greater than 1.0 indicate performance inferior to xylene. To offset the additional cost (and then some), recycling xylene and other aromatic solvent substitutes can help your lab save substantially on solvent spend, while also exponentially reducing your lab’s waste disposal costs—by up to 50 times, depending on how much solvent waste your lab generates. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. (18.9 L) Ea. However, they vary greatly in efficacy. What to Consider When Selecting Substitutes for Xylene, Paraffinic and isoparaffinic hydrocarbons (i.e., linear and branched-chain aliphatic hydrocarbons), D-limonenes (mostly produced from the steam distillation of orange peels), Paraffinic and isoparaffinic hydrocarbons that have been blended with glycol ethers. To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes… 0. 9990505 Xylene Substitute 1 gal. For reference, below are the types of xylene substitutes by their common brand names. Online product catalogs, news, articles, events, publications & more. The National Institute for Occupational Safety and Health (NIOSH) puts xylene’s Immediately Dangerous to Life or Health (IDLH) air concentration value at 900 ppm, which is essentially the point at which a worker will experience almost immediate negative health effects. What kind of validation process is required to switch to this substitute for ihc stains? Among various objections to using a substitute, some pathologists view xylene as being critical for proper tissue processing, staining and coverslipping (in part due to the paraffin infiltration, which renders the tissue section transparent), and lab managers may think substitutes are either too expensive and/or difficult to switch to. Two products of the alkane class were shown to be comparable to or better than xylene. Be the first to review! The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. May cause eyes, skin and respiratory tract irritation. Search results for Xylene Substitute at Sigma-Aldrich. We are interested to use it for both histo and cyto lab. Naphthenic solvents are clearly the best choices for replacing xylene and other aromatic solvents. Subject: Alternative to xylene. Research conducted by CBG Founder and Chairman, Gerald W. Camiener, Ph.D., demonstrated that the toxic aspects of aromatic solvents are associated with the double bonds present in their benzene rings—and that performance and chemical activities are associated with only the ring structure in the molecules. In reality, using and recycling xylene substitutes will actually reduce your lab’s solvent spend while promoting safety. Mr. Camiener is President of CBG Biotech, Ltd., Co., a manufacturer and supplier of recycling equipment to the laboratory, hospital and industrial markets. hbspt.cta._relativeUrls=true;hbspt.cta.load(2817229, 'efbe178a-a313-4e93-9aa4-c38978a2be44', {}); David Camiener founded Pragmatic Materials, Inc., a supplier of regulated materials and high purity biochemicals to the Pharmaceutical and Life Science industries. rené J.--- On Mon, 4/13/09, maureen bukhari <***@ucalgary.ca> wrote: From: maureen bukhari <***@ucalgary.ca> Subject: [Histonet] Xylene substitute To: ***@lists.utsouthwestern.edu Date: Monday, April 13, 2009, 11:41 AM Does anyone out there in histoland use Formula 83 by CBG Biotech as a Xylene, or xylol, is commonly manufactured for the purpose of a solvent, although can also serve as a paint thinner, cleaning agent or additional material. Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. Resistant as well to long-term exposure and immersion in safer clearing and deparaffinizing Xylene substitutes such as EZ Prep, Clearify™, Histo-Clear™, Formula 83™, Pro-Par and others. An essentially odorless, non greasy aliphatic hydrocarbon that replace Xylene as a clearant. Essentially, naphthenic solvents retain the solvent properties of aromatic solvents without the associated toxicities. *Please select more than one item to compare Xylene Substitute. How Xylene Compares to Xylene Substitutes, Relative drying times at room temperature, Solvent Comparisons: < 1.0 = superior to xylene; > 1.0 = inferior to xylene. Learn about how they’ve contributed to CBG customer success storie… Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. Storage: Store EMS Xylene Substitute at room temperature in a cool place. To learn more about the many benefits of Formula 83 ™, or one or our other aromatic solvent substitutes, … Xylene Substitute found in: Everclear™ Xylene Substitute, Histosol™ - Xylene Substitute, Neo-Clear (Xylene Substitute) For Microscopy, Xylene Substitute,.. Common Negative Health Effects of Xylene*, • Skin, eye and respiratory tract irritation, • Motor incoordination and impairment of equilibrium, • Flushing, redness of the face and a sensation of increased body heat, • Increased salivation, tremors, dizziness and confusion, • Severe abdominal pains, nausea, vomiting and loss of consciousness (if ingested), • Menstrual disorders and increased occurrence of miscarriages and birth defects, • Reduced blood platelet counts and increased chance of leukemia. Our HAP-free solvents are excellent solvent substitutes for use with many polymers, resins, oils, paraffins and greases. There is not sufficient data to predict the acute or chronic toxicity of xylene on birds or land animals. Delsym is an American brand-name over-the-counter cough syrup developed and marketed by the pharmaceutical company, Reckitt Benckiser. EMS Xylene Substitute is a flammable liquid and an aspiration hazard. You can see that naphthenic solvents are the only substitutes for xylene that outperform xylene itself. Sub-X® Xylene Substitute www.LeicaBiosystems.com #116 Page 1 of 8 Issue Date: 22 August 2013 Rev F SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND THE COMPANY 1.1 Product Identifier Trade Name Sub-X® Xylene Substitute Product # SDS # … XyliTUFF™ labels are also resistant to standard gas sterilization with ethylene oxide (759 mg/L for 1 hour, at 55°C, and 40-80% relative humidity). To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes, contact CBG Biotech today. Zero Xyleneâ„¢ is a gentle, yet effective clearant that will not over-harden specimens and is safe to use in both open and closed tissue processors. Terms Featured Answers. Safe and HAP-Free Solvents that Replace (Substitute for) Xylene, Toluene, dl-Limonene and other Aromatic SolventsXylene, Toluene, and other Aromatic Solvents can cause very serious medical problems and are classified by the U.S. Environmental Protection Agency as Hazardous Air Pollutants (HAP)But CBG Solvents don’t cause these medical problems and they are HAP-freeAnd CBG Solvents are as good or better solvents than their aromatic counterparts in almost every application, especially for polymers, resins, oils and greases – and they do not leave oily residues upon drying. Environmental XPRT is part of XPRT Media All Rights Reserved. See more. The table below compares all the major types of xylene substitutes side by side. We’ve created alternative, safer solutions for you to combat the toxicity of these commonly used solvents. The Environmental Protection Agency classifies many toxic solvents as HAPs, which have been proven to potentially introduce serious medical risks and problems through inhalation, skin/eye contact and ingestion. Some industries that apply the use of xylene include paint, leather, print, automobile, rubber, and biomedical and dentistry. Some of the direct applications for xylene replacements include: Surface preparation & cleaning; Post-clean-up This product will no longer be available on thermofisher.com after Dec. 28, 2020. David A. Camiener. Xylene is a classified Hazardous Air Pollutant (HAP), Formula 83 is HAP-free 83 g. Anybody can ... (The molecular formula of xylene is actually C 8 H 10. Of a total of 161 comments posted in HistoNet dealing with xylene substitutes, 68% were about alkane-based products, and of them, 76% referred to Clear-Rite, Formula 83, and ProPar. REF Xylene Substitute 1 gal. Naphthenic solvents not only perform better than xylene, they don’t have the same chemical structure, and therefore do not pose the health risks that are associated with xylene. There are many safer options available. Xylene, any of three isomeric dimethylbenzenes [which have the same chemical formula, C 6 H 4 (CH 3) 2, but different molecular structure], used as solvents, as components of aviation fuel, and as raw materials for the manufacture of dyes, fibres, and films.The three isomers, designated ortho (o), meta (m), and para (p), differ structurally only in the location of the methyl groups. Compare Products: Select up to 4 products. Xylene has high acute (short-term) toxicity to aquatic life. Fortunately xylene substitutes are easy to recycle. 1 Determination of a Chemical Formula ... (MW) of molecules by entering the chemical formulas (for example C3H4OH(COOH)3 ). What are other names or identifying information for xylene? Total xylenes - chemical information, properties, structures, articles, patents and more chemical data. Privacy, Our sites: Polychem® 36 is a xylene substitute that does not create any hazardous waste since it can be used numerous times and is recyclable. The contaminants are mostly alcohol, biological materials and paraffin. What is the WHMIS 1988 classification? Limitations: In extremely humid environments, EMS Xylene-Substitute may absorb moisture from the air. *Please select more than one item to compare Energy XPRT Agriculture XPRT Therefore, if you are monitoring the progress of longer electrophoresis run, Xylene Cyanol FF is the tracking dye of choice. There are also substitutes for xylene on the market that are effectively compatible, which means they perform just as well if not better than xylene and are relatively easy to switch to (although, at CBG Biotech, we always suggest you implement this change one procedure at a time so that you’re able to verify results before completely switching over to a substitute). An almost odourless formula with low toxicity levels, Clear-Advantage is another xylene substitute available from Polysciences, Inc. (see Resources). They structurally consist of substituted cyclohexane rings and are manufactured—by catalytically hydrogenating an aromatic solvent—to be essentially free of xylene and other dangerous double-bonded hydrocarbons. But only one option is as good as or better than xylene itself. Formula 83 costs 33% less than xylene (Formula 83 = 0.67 xylene). But only one option is as good as or better than xylene itself. 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Rights Reserved low, which means they don ’ t become overpowering with prolonged.., limonenes and alkanes, for paraffin tissue processing leather, print, automobile, rubber and. Stainers or for tissue processing as well compares All the major types of xylene include paint, leather print... Of naphthenic solvents retain the solvent properties of aromatic solvents without the associated toxicities short-term. Delsym is dextromethorphan hydrobromide, an anti-cough agent approved by the FDA in 3! Used the Formula 83 for about a year and we were happy with.!, skin and respiratory tract irritation cannabis Applications similar in performance toxicity levels, but their effectiveness as in... Types of xylene substitutes are now available, a viable alternative but only one option is good... You are monitoring the progress of longer electrophoresis run, xylene Cyanol FF is the tracking dye typically migrates the... Like xylene—can pose significant health risks, resins, oils, paraffins and.!